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| CAS: | 103980-44-5 |
| MF: | C19H18ClN5O7S3 |
| MW: | 560.02 |
| EINECS: | 206-169-9 |
Function of Ceftiofur hydrochloride:
1. protects epithelial cell membranes in the stomach and restores them to their normal metabolism;
2. acts as an antioxidant and protects the stomach from alcohol and smoking-induced damage;
3 has anti-inflammatory properties and moderates production of interleukin-8;
4. adheres to ulcerations, acts as a barrier between them and stomach acids and helps to heal them;
5. inhibits activity of Helicobacter pylori bacteria;
6. does not interfere with the production of prostaglandins essential to the mucosal lining of the stomach;
7.strengthens these mucosal linings and stimulates production of protective mucous.
Specification of Ceftiofur hydrochloride:
|
ITEMS |
SPECIFICATIONS |
RESULTS |
|
|
Appearance |
White to Off-white Crystalline powder |
Conform |
|
|
Identification |
The retention time of the principal peak in the chromatogram obtained with the test solution correspoonds to that of the principal peak in the chromatogram obtained with reference solution. |
Conform |
|
|
Reaction of Chloride |
Conform |
||
|
Appearance of solution |
Clarity |
Not stronger than No.1 Turbidity Standard |
<1 |
|
Color |
Not darker than standard solution Y9 |
<8 |
|
|
Solubility |
Soluble in N, N- Dimethylacetamide, slightly soluble in 5% of sodium bicarbonate and methanol. |
Conform |
|
|
PH |
2.0~3.0 |
2.2 |
|
|
Water Content |
1.5%~4.0% |
1.6% |
|
|
Specific optical Rotation |
-115°~-127° |
-117° |
|
|
Heavy metal |
NMT 0.0020% |
Conform |
|
|
Residue of ignition |
NMT 0.20% |
0.15% |
|
|
Related substances |
The biggest impurity |
NMT 0.20% |
0.09 |
|
Total impurities |
NMT 1.50% |
0.38 |
|
|
Residue solvents |
Ethyl Acetate |
NMT 0.5000% |
0 |
|
THF |
NMT 0.0720% |
0.006 |
|
|
Acetone |
NMT 0.5000% |
0.2739% |
|
|
Benzene |
NMT 0.0002% |
0.0001 |
|
|
Assay |
Ceftiofur Hydrochloride |
NLT 98.0% |
100.4% |
|
Chloride |
6.0%~6.5% |
6.2% |
|
|
Bacterial Endotoxin |
Less than 0.20EU/mg |
Conform |
|
|
Sterility |
Conforms the test |
Conform |
|
|
Particle size |
D (0,1) |
<1 |
1.8 |
|
D (0,5) |
<4 |
1.4 |
|
|
D (0,9) |
<7 |
3.7 |
|
|
D (1,0) |
<10 |
4.2 |
|
|
CONCLUSION |
THE TEST RESULTS CONFORMS TO THE SPECIFICATION |
||
Qingdao Sigma Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co.,Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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