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Acadesine is a cell permeable activator of AMPactivated protein kinase , a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation with Acadesine mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.f
| Name | Acadesine |
| Synonyms |
5-Amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide |
| CAS NO. | 2627-69-2 |
|
Molecular Formula |
C9H14N4O5 |
| Molecular Weight | 258.23 |
| EINECS | 220-097-5 |
| Appearance | White Powder |
| Purity | 99% Min |
| M.P. | 214-215 ºC |
Acadesine is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase activity. The drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.
(1) Applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis.
(2) Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.
(3) Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.
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