Glycopyrrolate is a medication of the muscarinic anticholinergic group. It does not cross the blood-brain barrier and consequently has no to few central effects. A synthetic quaternary amine, it is available in oral and intravenous (i.v.) forms. With counterion, it is known as glycopyrronium bromide.
Glycopyrrolate blocks muscarinic receptors, thus inhibiting cholinergic transmission.
Product name |
Glycopyrrolate |
Cas number |
596-51-0 |
Appearance |
White powder |
Melting point |
193 - 194.5 |
MF |
C19H28BrNO3 |
Density |
1.3222 (rough estimate) |
Refractive index |
1.6200 (estimate) |
MW |
398.33452 |
Glycopyrrolate is a quaternary ammonium anticholinergic drug, which has the effect of inhibiting gastric secretion and regulating gastrointestinal motility. It also has a stronger anti-saliva secretion effect than atropine, but it has no central anticholinergic activity and can be quickly taken after oral administration. Anti-acid, antispasmodic and analgesic.
This product is an anticholinergic drug. It is rarely used clinically. It can selectively act on the gastrointestinal tract and has a strong inhibitory effect on gastric secretion. Used for ulcer disease, gastritis, hyperacidity, etc. This product is a quaternary ammonium antimuscarinic drug. Its surrounding effects are similar to atropine. However, this product has a strong inhibitory effect on glandular secretion. It is mostly used for pre-anaesthesia administration in clinical practice. It can also be used as an auxiliary medicine for peptic ulcer and relieving visceral spasm.
Glycopyrrolate is a typical anticholinergic and possesses,at adequate dosage levels, the atropine-like effectscharacteristic of this class of drugs. It has a spasmolyticeffect on the musculature of the GI tract as well as the genitourinarytract. It diminishes gastric and pancreatic secretionsand the quantity of perspiration and saliva. Its sideeffects are also typically atropine-like (i.e., dryness of themouth, urinary retention, blurred vision, constipation).Glycopyrrolate is a more potent antagonist on M1 than onM2 and M3 receptors. The low affinity of M2 receptorsmay, in part, explain the low incidence of tachycardiaduring use of this drug as an antispasmodic.77 Because ofits quaternary ammonium character, glycopyrrolate rarelycauses CNS disturbances, although in sufficiently highdosage, it can bring about ganglionic and myoneural junctionblock.
For use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions and to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubat
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Shipping Terms |
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Company Profile
Qingdao Sigma Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co.,Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.