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Mebendazole is thought to kill worms byselectively inhibiting the synthesis of microtubules, impairing the parasite'sability to utilise glucose.
drug interaction:cimetidine raisesserum mebendazole levels, increasing its effectiveness.(toxic epidermalnecrolysis) when mebendazole is combined with high doses of metronidazole.
Mebendazole is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells: thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths. The drug is a highly effective broad spectrum antihelminitic indicated for the treatment of nematode infestations, including round worm, whip worm, thread worm, and hook worm. It is poorly absorbed and has no systemic effects.
| Items | Specification | results |
| Characteristic | A white or almost white powder | Almost white powder |
| Solubility | Practically insoluble in water,in alcohol and in methylene chloride,It shows polymorphism | conforms |
| Infrared Absorption | Comform to the spectrum obtained from Mebendazole RS. | conforms |
| Related substances |
Impurity G not more than 0.5% Any other individual impurity not more than 0.25% Total impurities not more than 1.0% |
<0.05% <0.05% <0.05% |
| Loss on drying | Not more than 0.5% | 0.06% |
| Residue on ignition | Not more than 0.1% | 0.06% |
| Partical size distribution | Particals smaller than 20um should be no less than 90% | conforms |
| Assay | It contains not less than 99.0% and not more than 101.0% of C16H13N3O3 calculated on the dried basis | 99.8% |
Qingdao Sigma Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co.,Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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