| Customization: | Available |
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| Powder: | Yes |
| Customized: | Non-Customized |
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Urokinase is a thrombolytic agent extracted from human fresh urine. It can activate plasminogen to plasmin, with the subsequent hydrolysis of fibrin and dissolution of thrombi.This product is mainly used in the treatment of acute myocardial infarction, acute cerebral thrombosis, occlusion of cerebral blood vessel, peripheral arteriovenous thrombi, central retinal arteriovenous thrombi and other infarction diseases due to freshly formed clot.Urokinase is produced by the human renal tubular epithelial cells of a serine protease, for an amorphous white powder, soluble in water. Dilute solution properties is not stable, must be fresh with, and shall not be diluted with acid solution. Freeze-dried state can be stable for several years. Urokinase is very selective specificity of proteolytic enzymes. This article on the activity of synthetic substrate with trypsin and fibrinolytic enzyme approximation, also has the esterase vigor.
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CAS No: 9039-53-6 MF: C21H25BrN2O3 MW: 433.35 EINECS: 232-917-9 |
Urokinase is isolated from the urine of healthy people, or an enzyme obtained from the tissue culture of human renal protein. By the molecular weight for 33000 (LMW-tcu-PA) and 54000 (HMW-tcu-PA) consists of two parts. This product directly on endogenous fibrinolytic system can catalyze the cleavage of plasminogen into plasmin, which can degrade the fibrin clots also can degrade the circulating Fibrinogen, coagulation factor v and factor VIII, and Thrombolysis role to play. The product of the newly formed blood clots work faster and better. This product also improves the effect of ADP enzyme activity, inhibition of ADP-induced platelet aggregation, preventing thrombosis. This product after the intravenous drip, fibrinolytic activity in the patients with markedly improved; stopped a few hours later, fibrinolytic enzymes levels.
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