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Apocynin is a methoxy-substituted catechol that is commonly used as an inhibitor of Mox and Nox (NADPH oxidase) (IC50=10μM). Because of Abocynin's inhibition of NADPH oxidase, ROS production is also inhibited. Studies show the compound's ability to decrease superoxide generation in bovine pulmonary arteries as well as neutrophils and macrophages (10 mM). In experimental rats, apocynin has displayed anti-inflammatory activity and can improve endothelial function by reducing oxidative stress and improved NO bioavailability. Reportedly prevents phagocytosis of MBP (myelin) by macrophages. Also has proven to be a useful product for studying NO-regulated processes in plants.
| Product: | Acetovanillone/Apocynin | |||||||||
| CAS: | 498-02-2 | |||||||||
| Molecular formula: | C9H10O3 | |||||||||
| Molecular weight: | 166.176 | |||||||||
| Physical Description: | White crystal powder | |||||||||
| Biological Source: | Vanilla | |||||||||
| Biological Use/Importance: | Cardiac agent | |||||||||
| Melting Point: | Mp 115ºC | |||||||||
| Assay: | ≥ 98% | |||||||||
| USES: | Used for content determination of/identification/pharmacology experiment, etc | |||||||||
| Storage conditions: | 2-8°C refrigerated, sealed, avoid light | |||||||||
| The period of validity: | 2 years | |||||||||
| Availability: | The spot | |||||||||
Qingdao Sigma Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co.,Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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