High Purity Nootropic Agent Powder Donepezil Hydrochloride CAS 120011-70-3

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Elderly, Children, Adult
• Purity: >99%
• Specification: standard
• Model NO.: 120011-70-3
• Trademark: QDSIGMA
• Origin: China
• Production Capacity: 50000000

Product Description

Product name	Donepezil hydrochloride
Synonyms	2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
CAS No.	120011-70-3
Molecular formula	C24H29NO3.HCl
Molecular weight	415.95
Specifications
ITEMS	SPECIFICATIONS		RESULTS
APPEARANCE	WHITE OR ALMOST WHITE CRYSTALLINE POWDER		CONFORMS
SOLUBILITY	TO MATCH WORKING STANDARD		CONFORMS
IDENTIFICATION	1) BY UV ABSORPTION,TO MATCH WORKING STANDARD 2) BY IR ABSORPTION,TO MATCH WORKING STANDARD		CONFORMS     CONFORMS
PH	4.0-7.0		5.47
MELTING POINT	216-220°C		218-220°C
RELATED SUBSTANCE
TOTAL		≤1.80%	0.07%
SINGLE IMPURITY (UNKNOWN)		≤0.50%	<0.1%
LOSS ON DRYING		≤1.0%	0.03%
RESIDUE ON IGNITION		≤0.10%	0.08%
HEAVY METAL		≤10 PPM	<10 PPM
ASSAY		≥99.0%	99.75%
CONCLUSION		CONFORMS TO THE ENTERPRISE STANDARD

 

Donepezil hydrochloride is a long-acting Alzheimer's disease (AD) in the symptomatic treatment drugs. AD is a kind of memory loss as the main performance, accompanied by other cognitive impairment of acquired intelligence decline. Nearly 30 years of research show: AD progressive degeneration of cholinergic neurons is memory loss, disorientation, personality changes and behavioral reasons, such cholinergic theory has been confirmed by histological study.

Donepezil hydrochloride is a second-generation cholinesterase (ChE) inhibitor, its therapeutic effect is reversibly inhibiting acid hydrolysis of acetylcholine acetylcholinesterase (AchE) caused by increased content of acetylcholine receptor sites. Donepezil may have other mechanisms, including the disposal of the direct effect of the peptide, neurotransmitter receptors, or Ca2 + channels.
 
Donepezil hydrochloride selection of AchE affinity than to butyrylcholinesterase (BchE) 1250 times stronger, it can inhibit the brain tissue ChE, but on the heart (myocardium) or small intestine (smooth) had no effect, probably on the chest organization (rhabdomyosarcoma) role; on the central nervous toxicity than tacrine.

Package & Shipping

 

 

 

 

 

Company Information 

Qingdao Sigma Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Qingdao Sigma Chemical Co.,Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.


Q1: Are you a manufacturer?
Answer: Yes, we are factory founded on 2002.
 
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Q4:Can you give me a discount price?
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free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
 
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A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
 
Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.