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Product name: Arecoline Hydrobromide
CAS No.: 300-08-3
Assay: HPLC/ESI-MS
Molecular formula : C8H13NO2.HBr
Molecular weight : 236.11
Appearance: White powder
Recoline is a natural alkaloid that is found in the betel nut of the Areca palm. It is an agonist of the muscarinic acetylcholine receptors with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively. Generally, arecoline causes smooth muscle contraction. Arecoline and other muscarinic receptor agonists have been shown to improve learning and memory and may prove to be useful in treating dementia.
Certification of Analysis
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Items
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Specification
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Appearance
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White fine Powder
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Ode
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Characteristic
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Taste
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Characteristic
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Paiticle size
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Pass 80 mesh
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Loss on drying
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≤5%
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Heavy metals
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<20ppm
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As
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<2ppm
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Pb
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<5ppm
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Assay
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Result
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Total Plate Count
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<10000cfu/g or <1000cfu/g(Irradiation)
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Yeast & Mold
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<1000cfu/g or 100cfu/g(Irradiation)
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E.Coli
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Negative
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Salmonella
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Negative
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Function&Application
(1) It has the heart stimulating effectarecoline hydrobromide.
(2) Anti-cancer and anti inflammatoryarecoline hydrobromide.
(3) It can be used to local anesthesia, refrigeration, anti-inflammation and detumescencearecoline hydrobromide.
(1) It has the heart stimulating effectarecoline hydrobromide.
(2) Anti-cancer and anti inflammatoryarecoline hydrobromide.
(3) It can be used to local anesthesia, refrigeration, anti-inflammation and detumescencearecoline hydrobromide.
(4) It used in sweating profusely with body temperature dropping; muscle spasm in choleraarecoline hydrobromide.
(5) It used in the treatment of rheumatism, intermittent fevers and acute inflammatory infectionsarecoline hydrobromide.
Owing to its muscarinic and nicotinic agonist properties, arecoline has shown improvement in the learning ability of healthy volunteers. Since one of the hallmarks of Alzheimer's disease is a cognitive decline, arecoline was suggested as a treatment to slow down this process and arecoline administered intravenously did indeed show modest verbal and spatial memory improvement in Alzheimer's patients, though due to arecoline's possible carcinogenic properties,it is not the first drug of choice for this degenerative disease.
Arecoline has also been used medicinally as an antihelmintic (a drug against parasitic worms).
Qingdao Sigma Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co.,Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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