| Customization: | Available |
|---|---|
| Powder: | Yes |
| Customized: | Customized |
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Product Name: Galantamine Hydrobromide
Appearance: White to off white powder
Molecular Formula: C17H21NO3.HBr
Molecular Weight: 368.27
CAS Number: 1953-04-4
EINECS: 217-780-5
Melting point: 258ºC~264ºC
Galantamine is used for the treatment of mild to moderate Alzheimer's disease and various other
memory impairments, particularly those of vascular origin. It is an alkaloid that is obtained
synthetically or from the bulbs and flowers of Galanthus Caucasicus (Caucasian snowdrop,
Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) and related genera like Narcissus
(daffodil)), Leucojum(snowflake) and Lycoris including Lycoris radiata (Red Spider Lily).
Galanthamine is natural extracted from lycoris radiate,is a tertiary alkaloid derived from snow drop and closely related species. It acts as a reversible competitive acetylcholinesterase (ACHE) inhibitor, while acts weaker on butyrylcholinesterse(BuChE).it is used in the treatment of disorders of the central nerbous system and may be used as an antidote to nonpolarizing muscle relaxants.Galanthamine hydrobromide is a white to almost white powder; sparingly soluble in water; insoluble chlo roform, ether and alcohol .
|
ITEMS |
SPECIFICATION |
RESULTS |
|
|
BP2010 /EP6 |
Appearance |
crystalline powder |
Conforms |
|
Melting point |
About 205°C |
206.4°C~206.7°C |
|
|
Identification |
Meet the requirements |
Conforms |
|
|
Appearance of solution |
Clear, not more intense than Y7 |
Conforms |
|
|
PH |
2.4~3.0 |
2.60 |
|
|
Loss on drying |
≤0.5% |
0.04% |
|
|
Sulphated ash |
≤0.1% |
0.01% |
|
|
Heavy metals |
≤20 ppm |
<20 ppm |
|
|
Related substances |
≤0.25% |
Conforms |
|
|
Assay |
99.0%~101.0% |
99.8% |
|
|
USP32 |
Identification |
Meet the requirements |
Conforms |
|
Loss on drying |
≤0.5% |
0.04% |
|
|
Residue on ignition |
≤0.1% |
0.01% |
|
|
Heavy metals |
≤0.003% |
<0.003% |
|
|
Residue solvent - Ethanol |
≤0.5% |
<0.04% |
|
|
Chloride |
16.9%~17.6% |
17.1% |
|
|
Assay |
98.0%~102.0% |
100.0% |
|
|
Conclusion: The product complies with BP2010/USP32/EP6 standard |
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(1) Anti-cholinesterase .
(2) Stimulate and inhibit acetylcholinesterase, regulate intracephalic nicotine receptor position.
(3) Cures the infantile paralysis sequelae, sweeny and myasthenia gravis pseudoparalytica, etc.
(4) Improve the recognition function of light, mild Alzheimer disease patients significantly, and delay the process of function decrease of brain cells.
(5) Improve the conduction between nerve and muscle.
1. Galanthamine Hydrobromide is mainly used in myasthenia gravis, poliovirus quiescent stage and sequela, also in polyneuritis, funiculitis and sensorimotor barrier caused by nervous system disease or traumatism;
2. Galanthamine Hydrobromide is also used in Alzheimer's disease, has the principal function for dement and dysmnesia caused by organic brain damage.
Qingdao Sigma Chemical Co., Ltd.is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co., Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
Qingdao Sigma Chemical Co., Ltd has become the "Top 500 Chinese manufacturing companies",
"Top 20 of global chemical sales".Qingdao Sigma Chemical Co., Ltd has 21 subsidiaries and holding companies.
Q1: Are you a manufacturer?
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free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.
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Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
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