| Product Name: |
Itopride hydrochloride |
| Synonyms: |
Hsr803;N-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxybenzamidemonohydr;N-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4-dimethoxy-benzamide hydrochloride;N-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxy-benzamidmonohy;N-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxy-benzamidmonohydrochloride;N-(4-(2-(dimethylamino)ethoxy)benzyl)-3,4-dimethoxidebenzamidehydrochloride;ITOPRIDE HCL;ITOPRIDE HYDROCHLORIDE |
| CAS: |
122892-31-3 |
| MF: |
C20H27ClN2O4 |
| MW: |
394.89 |
| EINECS: |
602-905-1 |
| Product Categories: |
Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Itopride;Amines;Aromatics |
| Mol File: |
122892-31-3.Mol |
| Molecular Structure: |
|
Itopride, a gastroprokinetic benzamide derivative was launched in Japan for the relief of gastrointestinal symptoms in patients with chronic gastritis.Ltopride is a dopamine D2-receptor antagonist that stimulates acetylcholine (Ach) release on the postganglionic cholinergic neurons to cause Ach accumulation at muscarinic receptors and, therefore, enhances Ach-induced gastric contractions.In animal models, itopride was reported to increase GI transit and gastric emptying.
Chemical Properties
| Melting point |
194-1950C |
| Storage temp. |
-20ºC Freezer |
| Solubility |
H2O:≥48mg/mL |
| Form |
Powder |
| Color |
White to tan |
| Λmax |
258nm(MeOH)(lit.) |
Typically, itopride is indicated in the treatment of GI symptoms caused by reduced GI motility:
• dyspepsia of a non-ulcer/dysmotility type (gastric "fullness", discomfort, and possible pain)
• gastroparesis (delayed gastric emptying)
• anorexia
• heartburn
• regurgitation
• bloating
• nausea and vomiting
• other possible gastric, prolactin, or dopamine related conditions
Itopride is typically taken three times a day. The dose is usually taken on an empty stomach about an hour before meals. However, the dosage and details of administration may vary depending on the patient's age, symptoms, and other factors.
Itopride was shown to significantly improve symptoms in patients with functional dyspepsia and motility disorders in placebo-controlled trials.
These studies concluded that the reduction in the severity of symptoms of functional dyspepsia after 8 weeks of treatment with itopride indicated that itopride was significantly superior to placebo and that itopride yielded a greater rate of response than placebo in significantly reducing pain and fullness.
Package & Shipping
Company Information
Qingdao Sigma Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.
The aim of Qingdao Sigma Chemical Co.,Ltd is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.
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